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Lymphotoxin β receptor-mediated NFκB signaling promotes glial lineage differentiation and inhibits neuronal lineage differentiation in mouse brain neural stem/progenitor cells
BACKGROUND: Lymphotoxin (LT) is a lymphokine mainly expressed in lymphocytes. LTα binds one or two membrane-associated LTβ to form LTα(2)β(1) or LTα(1)β(2) heterotrimers. The predominant LTα(1)β(2) binds to LTβ receptor (LTβR) primarily expressed in epithelial and stromal cells. Most studies on LTβR...
Autores principales: | Xiao, Xiao, Putatunda, Raj, Zhang, Yonggang, Soni, Priya V., Li, Fang, Zhang, Ting, Xin, Mingyang, Luo, Jin Jun, Bethea, John R., Cheng, Yuan, Hu, Wenhui |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819232/ https://www.ncbi.nlm.nih.gov/pubmed/29463313 http://dx.doi.org/10.1186/s12974-018-1074-z |
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