Dacomitinib potentiates the efficacy of conventional chemotherapeutic agents via inhibiting the drug efflux function of ABCG2 in vitro and in vivo

BACKGROUND: ATP-binding cassette subfamily G member 2 (ABCG2), a member of the ABC transporter superfamily proteins, mediates multidrug resistance (MDR) by transporting substrate anticancer drugs out of cancer cells and decreasing their intracellular accumulation. MDR is a major hurdle to successful...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Xiaoran, To, Kenneth K. W., Chen, Zhen, Wang, Xiaokun, Zhang, Jianye, Luo, Min, Wang, Fang, Yan, Shirong, Fu, Liwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819299/
https://www.ncbi.nlm.nih.gov/pubmed/29458405
http://dx.doi.org/10.1186/s13046-018-0690-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819299/
https://www.ncbi.nlm.nih.gov/pubmed/29458405
http://dx.doi.org/10.1186/s13046-018-0690-x

Ejemplares similares