Cargando…

Dacomitinib potentiates the efficacy of conventional chemotherapeutic agents via inhibiting the drug efflux function of ABCG2 in vitro and in vivo

BACKGROUND: ATP-binding cassette subfamily G member 2 (ABCG2), a member of the ABC transporter superfamily proteins, mediates multidrug resistance (MDR) by transporting substrate anticancer drugs out of cancer cells and decreasing their intracellular accumulation. MDR is a major hurdle to successful...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Xiaoran, To, Kenneth K. W., Chen, Zhen, Wang, Xiaokun, Zhang, Jianye, Luo, Min, Wang, Fang, Yan, Shirong, Fu, Liwu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819299/ https://www.ncbi.nlm.nih.gov/pubmed/29458405 http://dx.doi.org/10.1186/s13046-018-0690-x

Ejemplares similares

Effect of ceritinib (LDK378) on enhancement of chemotherapeutic agents in ABCB1 and ABCG2 overexpressing cells in vitro and in vivo
por: Hu, Jing, et al.
Publicado: (2015)

Rociletinib (CO-1686) enhanced the efficacy of chemotherapeutic agents in ABCG2-overexpressing cancer cells in vitro and in vivo
por: Zeng, Fanpu, et al.
Publicado: (2020)

CM082 Enhances the Efficacy of Chemotherapeutic Drugs by Inhibiting the Drug Efflux Function of ABCG2
por: Xu, Lejia, et al.
Publicado: (2019)

CM082 Enhances the Efficacy of Chemotherapeutic Drugs by Inhibiting the Drug Efflux Function of ABCG2
por: Xu, Lejia, et al.
Publicado: (2023)

Lazertinib improves the efficacy of chemotherapeutic drugs in ABCB1 or ABCG2 overexpression cancer cells in vitro, in vivo, and ex vivo
por: Fan, Yingfang, et al.
Publicado: (2022)

Effects of dacomitinib on the pharmacokinetics of poziotinib in vivo and in vitro
por: Ji, Weiping, et al.
Publicado: (2021)

Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells
por: Wu, Shaocong, et al.
Publicado: (2018)

Alectinib (CH5424802) antagonizes ABCB1- and ABCG2-mediated multidrug resistance in vitro, in vivo and ex vivo
por: Yang, Ke, et al.
Publicado: (2017)

Correction: Alectinib (CH5424802) antagonizes ABCB1- and ABCG2-mediated multidrug resistance in vitro, in vivo and ex vivo
por: Yang, Ke, et al.
Publicado: (2020)

WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells
por: Zhang, Hui, et al.
Publicado: (2014)

Cetuximab enhanced the efficacy of chemotherapeutic agent in ABCB1/P-glycoprotein-overexpressing cancer cells
por: Wang, Fang, et al.
Publicado: (2015)

ABCG2-overexpressing H460/MX20 cell xenografts in athymic nude mice maintained original biochemical and cytological characteristics
por: Zhang, Wei, et al.
Publicado: (2017)

Lapatinib promotes the incidence of hepatotoxicity by increasing chemotherapeutic agent accumulation in hepatocytes
por: Dai, ChunLing, et al.
Publicado: (2015)

Author Correction: ABCG2-overexpressing H460/MX20 cell xenografts in athymic nude mice maintained original biochemical and cytological characteristics
por: Zhang, Wei, et al.
Publicado: (2020)

Olmutinib (HM61713) reversed multidrug resistance by inhibiting the activity of ATP-binding cassette subfamily G member 2 in vitro and in vivo
por: Zhang, Zhiqiang, et al.
Publicado: (2018)

Molecular basis of cholesterol efflux via ABCG subfamily transporters
por: Sun, Yingyuan, et al.
Publicado: (2021)

Molecular Correlates of In Vitro Responses to Dacomitinib and Afatinib in Bladder Cancer
por: Tamura, Shuzo, et al.
Publicado: (2018)

Secalonic acid D induces cell apoptosis in both sensitive and ABCG2-overexpressing multidrug resistant cancer cells through upregulating c-Jun expression
por: Zhang, Hong, et al.
Publicado: (2019)

Reversal effect of FW-04-806, a macrolide dilactone compound, on multidrug resistance mediated by ABCB1 and ABCG2 in vitro and in vivo
por: Zhang, Zhiqiang, et al.
Publicado: (2019)

Chemotherapeutic drugs stimulate the release and recycling of extracellular vesicles to assist cancer cells in developing an urgent chemoresistance
por: Wang, Xiaokun, et al.
Publicado: (2019)

CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo
por: Dietrich, Joerg, et al.
Publicado: (2006)

KD025, an anti-adipocyte differentiation drug, enhances the efficacy of conventional chemotherapeutic drugs in ABCG2-overexpressing leukemia cells
por: Jing, Wen, et al.
Publicado: (2020)

Incorporation of drug efflux inhibitor and chemotherapeutic agent into an inorganic/organic platform for the effective treatment of multidrug resistant breast cancer
por: Dong, Yang, et al.
Publicado: (2019)

AhR-activating pesticides increase the bovine ABCG2 efflux activity in MDCKII-bABCG2 cells
por: Kuhnert, Lydia, et al.
Publicado: (2020)

Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier
por: Kumar, Jeyan S., et al.
Publicado: (2016)

RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes
por: Daffu, Gurdip, et al.
Publicado: (2015)

The Effect of Hepatic Impairment on the Pharmacokinetics of Dacomitinib
por: Piscitelli, Joseph, et al.
Publicado: (2022)

Inhibitory effect of valproic acid on bladder cancer in combination with chemotherapeutic agents in vitro and in vivo
por: WANG, DEGUI, et al.
Publicado: (2013)

In vivo combination of misonidazole and the chemotherapeutic agent CCNU.
por: Siemann, D. W.
Publicado: (1981)

The influence of ABCG2 polymorphism on erlotinib efflux in the K562 cell line
por: Svedberg, Anna, et al.
Publicado: (2020)

Structural basis for abscisic acid efflux mediated by ABCG25 in Arabidopsis thaliana
por: Ying, Wei, et al.
Publicado: (2023)

SR-BI associates with ABCG1 and inhibits ABCG1-mediated cholesterol efflux from cells to high-density lipoprotein 3
por: Song, Guohua, et al.
Publicado: (2012)

Poziotinib Inhibits the Efflux Activity of the ABCB1 and ABCG2 Transporters and the Expression of the ABCG2 Transporter Protein in Multidrug Resistant Colon Cancer Cells
por: Zhang, Yongchao, et al.
Publicado: (2020)

Venetoclax, a BCL-2 Inhibitor, Enhances the Efficacy of Chemotherapeutic Agents in Wild-Type ABCG2-Overexpression-Mediated MDR Cancer Cells
por: Wang, Jing-Quan, et al.
Publicado: (2020)

Efficacy of dacomitinib in patients with EGFR‐mutated NSCLC and brain metastases
por: Zhang, Jinyao, et al.
Publicado: (2021)

Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux
por: Sankaranarayanan, Sandhya, et al.
Publicado: (2009)

Effect of ABCG2/BCRP Expression on Efflux and Uptake of Gefitinib in NSCLC Cell Lines
por: Galetti, Maricla, et al.
Publicado: (2015)

GSK2606414 Sensitizes ABCG2-Overexpressing Multidrug-Resistant Colorectal Cancer Cells to Chemotherapeutic Drugs
por: Yu, Ze-Zhong, et al.
Publicado: (2023)

ABCG1 maintains high-grade glioma survival in vitro and in vivo
por: Chen, Yi-Hsien, et al.
Publicado: (2016)

Synergistic Effects of Plant Derivatives and Conventional Chemotherapeutic Agents: An Update on the Cancer Perspective
por: Pezzani, Raffaele, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_t62bc0cnahslnt4tctrjflgcno