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Methyltransferases of gentamicin biosynthesis

Gentamicin C complex from Micromonospora echinospora remains a globally important antibiotic, and there is revived interest in the semisynthesis of analogs that might show improved therapeutic properties. The complex consists of five components differing in their methylation pattern at one or more s...

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Detalles Bibliográficos
Autores principales: Li, Sicong, Guo, Junhong, Reva, Anna, Huang, Fanglu, Xiong, Binbin, Liu, Yuanzhen, Deng, Zixin, Leadlay, Peter F., Sun, Yuhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819394/
https://www.ncbi.nlm.nih.gov/pubmed/29358400
http://dx.doi.org/10.1073/pnas.1711603115