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Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats

Neuropathic pain is caused by peripheral nerve injury (PNI). One hallmark symptom is allodynia (pain caused by normally innocuous stimuli), but its mechanistic underpinning remains elusive. Notably, whether selective stimulation of non-nociceptive primary afferent Aβ fibers indeed evokes neuropathic...

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Detalles Bibliográficos
Autores principales: Tashima, Ryoichi, Koga, Keisuke, Sekine, Misuzu, Kanehisa, Kensho, Kohro, Yuta, Tominaga, Keiko, Matsushita, Katsuyuki, Tozaki-Saitoh, Hidetoshi, Fukazawa, Yugo, Inoue, Kazuhide, Yawo, Hiromu, Furue, Hidemasa, Tsuda, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819669/
https://www.ncbi.nlm.nih.gov/pubmed/29468190
http://dx.doi.org/10.1523/ENEURO.0450-17.2018