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A simulation study on estimating biomarker–treatment interaction effects in randomized trials with prognostic variables

BACKGROUND: To individualize treatment decisions based on patient characteristics, identification of an interaction between a biomarker and treatment is necessary. Often such potential interactions are analysed using data from randomized clinical trials intended for comparison of two treatments. Tes...

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Detalles Bibliográficos
Autores principales:	Haller, Bernhard, Ulm, Kurt
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819679/ https://www.ncbi.nlm.nih.gov/pubmed/29463271 http://dx.doi.org/10.1186/s13063-018-2491-0

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