NS2 proteases from hepatitis C virus and related hepaciviruses share composite active sites and previously unrecognized intrinsic proteolytic activities

Over the recent years, several homologues with varying degrees of genetic relatedness to hepatitis C virus (HCV) have been identified in a wide range of mammalian species. HCV infectious life cycle relies on a first critical proteolytic event of its single polyprotein, which is carried out by nonstr...

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Detalles Bibliográficos
Autores principales: Boukadida, Célia, Fritz, Matthieu, Blumen, Brigitte, Fogeron, Marie-Laure, Penin, François, Martin, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819835/
https://www.ncbi.nlm.nih.gov/pubmed/29415072
http://dx.doi.org/10.1371/journal.ppat.1006863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819835/
https://www.ncbi.nlm.nih.gov/pubmed/29415072
http://dx.doi.org/10.1371/journal.ppat.1006863

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