Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors

Development of selective kinase inhibitors remains a challenge due to considerable amino acid sequence similarity among family members particularly in the ATP binding site. Targeting the activation loop might offer improved inhibitor selectivity since this region of kinases is less conserved. Howeve...

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Detalles Bibliográficos
Autores principales: Suebsuwong, Chalada, Pinkas, Daniel M., Ray, Soumya S., Bufton, Joshua C., Dai, Bing, Bullock, Alex N., Degterev, Alexei, Cuny, Gregory D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819902/
https://www.ncbi.nlm.nih.gov/pubmed/29409752
http://dx.doi.org/10.1016/j.bmcl.2018.01.044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819902/
https://www.ncbi.nlm.nih.gov/pubmed/29409752
http://dx.doi.org/10.1016/j.bmcl.2018.01.044

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