3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound

Ribonucleotide reductases (RNRs) convert ribonucleotides into deoxyribonucleotides, a reaction essential for DNA replication and repair. Human RNR requires two subunits for activity, the α subunit contains the active site, and the β subunit houses the radical cofactor. Here, we present a 3.3-Å resol...

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Detalles Bibliográficos
Autores principales: Brignole, Edward J, Tsai, Kuang-Lei, Chittuluru, Johnathan, Li, Haoran, Aye, Yimon, Penczek, Pawel A, Stubbe, JoAnne, Drennan, Catherine L, Asturias, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819950/
https://www.ncbi.nlm.nih.gov/pubmed/29460780
http://dx.doi.org/10.7554/eLife.31502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819950/
https://www.ncbi.nlm.nih.gov/pubmed/29460780
http://dx.doi.org/10.7554/eLife.31502

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