LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

Faithful chromosome segregation and genome maintenance requires the removal of all DNA bridges that physically link chromosomes before cells divide. Using C. elegans embryos we show that the LEM-3/Ankle1 nuclease defines a previously undescribed genome integrity mechanism by processing DNA bridges r...

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Detalles Bibliográficos
Autores principales: Hong, Ye, Sonneville, Remi, Wang, Bin, Scheidt, Viktor, Meier, Bettina, Woglar, Alexander, Demetriou, Sarah, Labib, Karim, Jantsch, Verena, Gartner, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820297/
https://www.ncbi.nlm.nih.gov/pubmed/29463814
http://dx.doi.org/10.1038/s41467-018-03135-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820297/
https://www.ncbi.nlm.nih.gov/pubmed/29463814
http://dx.doi.org/10.1038/s41467-018-03135-w

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