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LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis
Faithful chromosome segregation and genome maintenance requires the removal of all DNA bridges that physically link chromosomes before cells divide. Using C. elegans embryos we show that the LEM-3/Ankle1 nuclease defines a previously undescribed genome integrity mechanism by processing DNA bridges r...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820297/ https://www.ncbi.nlm.nih.gov/pubmed/29463814 http://dx.doi.org/10.1038/s41467-018-03135-w |