Induction of micronuclei by four cytostatic compounds in human hematopoietic stem cells and human lymphoblastoid TK6 cells

For mutagenicity testing, primary lymphocytes or mammalian cell lines are employed. However, the true target for carcinogenic action of mutagenic chemicals may be stem cells. Since hematopoietic cancers induced by chemical agents originate at the hematopoietic stem cell (HSC) stage and since one of...

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Detalles Bibliográficos
Autores principales: Hintzsche, Henning, Montag, Gracia, Stopper, Helga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820321/
https://www.ncbi.nlm.nih.gov/pubmed/29463873
http://dx.doi.org/10.1038/s41598-018-21680-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820321/
https://www.ncbi.nlm.nih.gov/pubmed/29463873
http://dx.doi.org/10.1038/s41598-018-21680-8

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