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A Single-Chain Photoswitchable CRISPR-Cas9 Architecture for Light-Inducible Gene Editing and Transcription

[Image: see text] Optical control of CRISPR-Cas9-derived proteins would be useful for restricting gene editing or transcriptional regulation to desired times and places. Optical control of Cas9 functions has been achieved with photouncageable unnatural amino acids or by using light-induced protein i...

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Detalles Bibliográficos
Autores principales: Zhou, Xin X., Zou, Xinzhi, Chung, Hokyung K., Gao, Yuchen, Liu, Yanxia, Qi, Lei S., Lin, Michael Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820652/
https://www.ncbi.nlm.nih.gov/pubmed/28938067
http://dx.doi.org/10.1021/acschembio.7b00603