Cargando…

Toward an integrated map of genetic interactions in cancer cells

Cancer genomes often harbor hundreds of molecular aberrations. Such genetic variants can be drivers or passengers of tumorigenesis and create vulnerabilities for potential therapeutic exploitation. To identify genotype‐dependent vulnerabilities, forward genetic screens in different genetic backgroun...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rauscher, Benedikt, Heigwer, Florian, Henkel, Luisa, Hielscher, Thomas, Voloshanenko, Oksana, Boutros, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820685/ https://www.ncbi.nlm.nih.gov/pubmed/29467179 http://dx.doi.org/10.15252/msb.20177656

Ejemplares similares

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families
por: Voloshanenko, Oksana, et al.
Publicado: (2017)

β-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells
por: Voloshanenko, Oksana, et al.
Publicado: (2018)

Time-resolved mapping of genetic interactions to model rewiring of signaling pathways
por: Heigwer, Florian, et al.
Publicado: (2018)

GenomeCRISPR - a database for high-throughput CRISPR/Cas9 screens
por: Rauscher, Benedikt, et al.
Publicado: (2017)

Genome-scale CRISPR screening at high sensitivity with an empirically designed sgRNA library
por: Henkel, Luisa, et al.
Publicado: (2020)

A global genetic interaction network by single-cell imaging and machine learning
por: Heigwer, Florian, et al.
Publicado: (2023)

RNA Interference (RNAi) Screening in Drosophila
por: Heigwer, Florian, et al.
Publicado: (2018)

Machine learning and image-based profiling in drug discovery
por: Scheeder, Christian, et al.
Publicado: (2018)

HTSvis: a web app for exploratory data analysis and visualization of arrayed high-throughput screens
por: Scheeder, Christian, et al.
Publicado: (2017)

Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells
por: Ambrosi, Giulia, et al.
Publicado: (2022)

A genetic interaction map of cell cycle regulators
por: Billmann, Maximilian, et al.
Publicado: (2016)

Refining Pathways: A Model Comparison Approach
por: Moffa, Giusi, et al.
Publicado: (2016)

Blockade of Wnt Secretion Attenuates Myocardial Ischemia–Reperfusion Injury by Modulating the Inflammatory Response
por: Meyer, Ingmar Sören, et al.
Publicado: (2022)

A map of directional genetic interactions in a metazoan cell
por: Fischer, Bernd, et al.
Publicado: (2015)

ERAD‐dependent control of the Wnt secretory factor Evi
por: Glaeser, Kathrin, et al.
Publicado: (2018)

A chemical–genetic interaction map of small molecules using high‐throughput imaging in cancer cells
por: Breinig, Marco, et al.
Publicado: (2015)

E-TALEN: a web tool to design TALENs for genome engineering
por: Heigwer, Florian, et al.
Publicado: (2013)

CRISPR library designer (CLD): software for multispecies design of single guide RNA libraries
por: Heigwer, Florian, et al.
Publicado: (2016)

Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells
por: Voloshanenko, Oksana, et al.
Publicado: (2013)

Wnt10b-GSK3β–dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells
por: Lin, Yu-Chih, et al.
Publicado: (2020)

K(ATP) channels modulate intrinsic firing activity of immature entorhinal cortex layer III neurons
por: Lemak, Maria S., et al.
Publicado: (2014)

A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila
por: Port, Fillip, et al.
Publicado: (2020)

Superresolution microscopy localizes endogenous Dvl2 to Wnt signaling-responsive biomolecular condensates
por: Schubert, Antonia, et al.
Publicado: (2022)

Metabolic balance in colorectal cancer is maintained by optimal Wnt signaling levels
por: Imkeller, Katharina, et al.
Publicado: (2022)

Quantitative maps of genetic interactions in yeast - Comparative evaluation and integrative analysis
por: Lindén, Rolf O, et al.
Publicado: (2011)

Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi
por: Axelsson, Elin, et al.
Publicado: (2011)

Integrating Selection Mapping With Genetic Mapping and Functional Genomics
por: Johnsson, Martin
Publicado: (2018)

Systematic epistatic mapping of cellular processes
por: Billmann, Maximilian, et al.
Publicado: (2017)

Towards a compendium of essential genes – From model organisms to synthetic lethality in cancer cells
por: Zhan, Tianzuo, et al.
Publicado: (2016)

Interaction of genetic variants towards increased cancer risk
por: Hammad, Seddik
Publicado: (2013)

Modularity and directionality in genetic interaction maps
por: Jaimovich, Ariel, et al.
Publicado: (2010)

A comparative map viewer integrating genetic maps for Brassica and Arabidopsis
por: Lim, Geraldine AC, et al.
Publicado: (2007)

An Integrated Genetic and Cytogenetic Map of the Cucumber Genome
por: Ren, Yi, et al.
Publicado: (2009)

Toward an interactive article: integrating journals and biological databases
por: Rangarajan, Arun, et al.
Publicado: (2011)

Mapping genetic interactions in cancer: a road to rational combination therapies
por: Tutuncuoglu, Beril, et al.
Publicado: (2019)

Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis
por: Vizeacoumar, Franco J., et al.
Publicado: (2010)

From E-MAPs to module maps: dissecting quantitative genetic interactions using physical interactions
por: Ulitsky, Igor, et al.
Publicado: (2008)

A physical map of the papaya genome with integrated genetic map and genome sequence
por: Yu, Qingyi, et al.
Publicado: (2009)

Towards mouse genetic-specific RNA-sequencing read mapping
por: Gobet, Nastassia, et al.
Publicado: (2022)

Towards a Genetic Linkage Map of the California Condor, an Endangered New World Vulture Species
por: Romanov, Michael N., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2a25lbf5utdgngtr78genhv0cl