Quantitative Prediction of Rate Constants for Aqueous Racemization To Avoid Pointless Stereoselective Syntheses

Racemization has a large impact upon the biological properties of molecules but the chemical scope of compounds with known rate constants for racemization in aqueous conditions was hitherto limited. To address this remarkable blind spot, we have measured the kinetics for racemization of 28 compounds...

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Detalles Bibliográficos
Autores principales: Ballard, Andrew, Ahmad, Hiwa O., Narduolo, Stefania, Rosa, Lucy, Chand, Nikki, Cosgrove, David A., Varkonyi, Peter, Asaad, Nabil, Tomasi, Simone, Buurma, Niklaas J., Leach, Andrew G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820753/
https://www.ncbi.nlm.nih.gov/pubmed/29072355
http://dx.doi.org/10.1002/anie.201709163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820753/
https://www.ncbi.nlm.nih.gov/pubmed/29072355
http://dx.doi.org/10.1002/anie.201709163

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