Dioscin overcome TKI resistance in EGFR-mutated lung adenocarcinoma cells via down-regulation of tyrosine phosphatase SHP2 expression

Resistance to tyrosine kinase inhibitors (TKIs) results in tumor relapse and poor prognosis in patients with lung adenocarcinoma. TKI resistance caused by epidermal growth factor receptor (EGFR) mutations at T790M and c-Met amplification occurs through persistent activation of the MEK/ERK and PI3K/A...

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Detalles Bibliográficos
Autores principales: Wang, Yao-Chen, Wu, De-Wei, Wu, Tzu-Chin, Wang, Lee, Chen, Chih-Yi, Lee, Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821048/
https://www.ncbi.nlm.nih.gov/pubmed/29483824
http://dx.doi.org/10.7150/ijbs.22209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821048/
https://www.ncbi.nlm.nih.gov/pubmed/29483824
http://dx.doi.org/10.7150/ijbs.22209

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