Rheostatic Control of Cas9-Mediated DNA Double Strand Break (DSB) Generation and Genome Editing

[Image: see text] We recently reported two novel tools for precisely controlling and quantifying Cas9 activity: a chemically inducible Cas9 variant (ciCas9) that can be rapidly activated by small molecules and a ddPCR assay for time-resolved measurement of DNA double strand breaks (DSB-ddPCR). Here,...

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Detalles Bibliográficos
Autores principales: Rose, John C., Stephany, Jason J., Wei, Cindy T., Fowler, Douglas M., Maly, Dustin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821106/
https://www.ncbi.nlm.nih.gov/pubmed/28895730
http://dx.doi.org/10.1021/acschembio.7b00652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821106/
https://www.ncbi.nlm.nih.gov/pubmed/28895730
http://dx.doi.org/10.1021/acschembio.7b00652

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