Effect of early embryonic deletion of huntingtin from pyramidal neurons on the development and long-term survival of neurons in cerebral cortex and striatum

We evaluated the impact of early embryonic deletion of huntingtin (htt) from pyramidal neurons on cortical development, cortical neuron survival and motor behavior, using a cre-loxP strategy to inactivate the mouse htt gene (Hdh) in emx1-expressing cell lineages. Western blot confirmed substantial h...

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Detalles Bibliográficos
Autores principales: Dragatsis, I., Dietrich, P., Ren, H., Deng, Y.P., Del Mar, N, Wang, H.B., Johnson, I.M., Jones, K.R., Reiner, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821111/
https://www.ncbi.nlm.nih.gov/pubmed/29274742
http://dx.doi.org/10.1016/j.nbd.2017.12.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821111/
https://www.ncbi.nlm.nih.gov/pubmed/29274742
http://dx.doi.org/10.1016/j.nbd.2017.12.015

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