iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction

The role of proinflammation, and specifically TNF-α, on downstream fibrosis and healing after cardiac injury remains unknown. Using iRhom2-deficient mice, which lack myeloid-specific shedding of TNF-α, we reveal increased macrophages (MΦs) that were skewed towards a more proinflammatory (M1) state a...

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Detalles Bibliográficos
Autores principales: Barnette, Damien N., Cahill, Thomas J., Gunadasa-Rohling, Mala, Carr, Carolyn A., Freeman, Matthew, Riley, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821194/
https://www.ncbi.nlm.nih.gov/pubmed/29415889
http://dx.doi.org/10.1172/jci.insight.98268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821194/
https://www.ncbi.nlm.nih.gov/pubmed/29415889
http://dx.doi.org/10.1172/jci.insight.98268

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