CLINICAL AND BIOLOGICAL IMPLICATIONS OF ANCESTRAL AND NON-ANCESTRAL IDH1 AND IDH2 MUTATIONS IN MYELOID NEOPLASMS

Mutations in isocitrate dehydrogenase 1/2 (IDH1/2(MT)) are drivers of a variety of myeloid neoplasms. As they yield the same oncometabolite, D-2-hydroxyglutarate, they are often treated as equivalent, and pooled. We studied the validity of this approach and found IDH1/2 mutations in 179 of 2119 myel...

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Detalles Bibliográficos
Autores principales: Molenaar, Remco J., Thota, Swapna, Nagata, Yasunobu, Patel, Bhumika, Clemente, Michael, Hirsh, Cassandra, Viny, Aaron D., Hosano, Naoko, Bleeker, Fonnet E., Meggendorfer, Manja, Alpermann, Tamara, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, van Noorden, Cornelis J.F., Radivoyevitch, Tomas, Caraway, Hetty, Makishima, Hideki, Miyano, Satoru, Sekeres, Mikkael A., Ogawa, Seishi, Haferlach, Torsten, Maciejewski, Jaroslaw P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821256/
https://www.ncbi.nlm.nih.gov/pubmed/25836588
http://dx.doi.org/10.1038/leu.2015.91

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821256/
https://www.ncbi.nlm.nih.gov/pubmed/25836588
http://dx.doi.org/10.1038/leu.2015.91

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