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Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein

The lack of a mutant phenotype in homozygous mutant individuals’ due to compensatory gene expression triggered upstream of protein function has been identified as genetic compensation. Whilst this intriguing process has been recognized in zebrafish, the presence of homozygous loss of function mutati...

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Detalles Bibliográficos
Autores principales: Sztal, Tamar E., McKaige, Emily A., Williams, Caitlin, Ruparelia, Avnika A., Bryson-Richardson, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821405/
https://www.ncbi.nlm.nih.gov/pubmed/29420541
http://dx.doi.org/10.1371/journal.pgen.1007212