Human SLFN5 is a Transcriptional Co-repressor of STAT1-Mediated Interferon Responses and Promotes the Malignant Phenotype in Glioblastoma

We provide evidence that the IFN-regulated member of the Schlafen (SLFN) family of proteins, SLFN5, promotes the malignant phenotype in glioblastoma multiforme (GBM). Our studies indicate that SLFN5 expression promotes motility and invasiveness of GBM cells, and that high levels of SLFN5 expression...

Descripción completa

Detalles Bibliográficos
Autores principales: Arslan, Ahmet Dirim, Sassano, Antonella, Saleiro, Diana, Lisowski, Pawel, Kosciuczuk, Ewa M., Fischietti, Mariafausta, Eckerdt, Frank, Fish, Eleanor N., Platanias, Leonidas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821504/
https://www.ncbi.nlm.nih.gov/pubmed/28671669
http://dx.doi.org/10.1038/onc.2017.205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821504/
https://www.ncbi.nlm.nih.gov/pubmed/28671669
http://dx.doi.org/10.1038/onc.2017.205

Ejemplares similares