Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation

T cells have a central function in mounting immune responses. However, mechanisms of their early activation by cognate antigens remain incompletely understood. Here we use live-cell multi-colour single-molecule localization microscopy to study the dynamic separation between TCRs and CD45 glycoprotei...

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Detalles Bibliográficos
Autores principales: Razvag, Yair, Neve-Oz, Yair, Sajman, Julia, Reches, Meital, Sherman, Eilon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821895/
https://www.ncbi.nlm.nih.gov/pubmed/29467364
http://dx.doi.org/10.1038/s41467-018-03127-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821895/
https://www.ncbi.nlm.nih.gov/pubmed/29467364
http://dx.doi.org/10.1038/s41467-018-03127-w

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