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Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation
T cells have a central function in mounting immune responses. However, mechanisms of their early activation by cognate antigens remain incompletely understood. Here we use live-cell multi-colour single-molecule localization microscopy to study the dynamic separation between TCRs and CD45 glycoprotei...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821895/ https://www.ncbi.nlm.nih.gov/pubmed/29467364 http://dx.doi.org/10.1038/s41467-018-03127-w |