Pathological histone acetylation in Parkinson’s disease: Neuroprotection and inhibition of microglial activation through SIRT 2 inhibition

Parkinson’s disease (PD) is associated with degeneration of nigrostriatal neurons due to intracytoplasmic inclusions composed predominantly of a synaptic protein called α-synuclein. Accumulations of α-synuclein are thought to ‘mask’ acetylation sites on histone proteins, inhibiting the action of his...

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Detalles Bibliográficos
Autores principales: Harrison, Ian F., Smith, Andrew D., Dexter, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Scientific Publishers Ireland 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821898/
https://www.ncbi.nlm.nih.gov/pubmed/29273397
http://dx.doi.org/10.1016/j.neulet.2017.12.037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821898/
https://www.ncbi.nlm.nih.gov/pubmed/29273397
http://dx.doi.org/10.1016/j.neulet.2017.12.037

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