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Pathological histone acetylation in Parkinson’s disease: Neuroprotection and inhibition of microglial activation through SIRT 2 inhibition

Parkinson’s disease (PD) is associated with degeneration of nigrostriatal neurons due to intracytoplasmic inclusions composed predominantly of a synaptic protein called α-synuclein. Accumulations of α-synuclein are thought to ‘mask’ acetylation sites on histone proteins, inhibiting the action of his...

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Detalles Bibliográficos
Autores principales:	Harrison, Ian F., Smith, Andrew D., Dexter, David T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Scientific Publishers Ireland 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821898/ https://www.ncbi.nlm.nih.gov/pubmed/29273397 http://dx.doi.org/10.1016/j.neulet.2017.12.037

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