Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development

Shank3 is a structural protein found predominantly at the postsynaptic density. Mutations in the SHANK3 gene have been associated with risk for autism spectrum disorder (ASD). We generated induced pluripotent stem cells (iPSCs) from control individuals and from human donors with ASD carrying microde...

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Detalles Bibliográficos
Autores principales: Kathuria, A, Nowosiad, P, Jagasia, R, Aigner, S, Taylor, R D, Andreae, L C, Gatford, N J F, Lucchesi, W, Srivastava, D P, Price, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822449/
https://www.ncbi.nlm.nih.gov/pubmed/28948968
http://dx.doi.org/10.1038/mp.2017.185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822449/
https://www.ncbi.nlm.nih.gov/pubmed/28948968
http://dx.doi.org/10.1038/mp.2017.185

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