Cargando…
Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development
Shank3 is a structural protein found predominantly at the postsynaptic density. Mutations in the SHANK3 gene have been associated with risk for autism spectrum disorder (ASD). We generated induced pluripotent stem cells (iPSCs) from control individuals and from human donors with ASD carrying microde...
Autores principales: | Kathuria, A, Nowosiad, P, Jagasia, R, Aigner, S, Taylor, R D, Andreae, L C, Gatford, N J F, Lucchesi, W, Srivastava, D P, Price, J |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822449/ https://www.ncbi.nlm.nih.gov/pubmed/28948968 http://dx.doi.org/10.1038/mp.2017.185 |
Ejemplares similares
-
Single-molecule fluorescence in-situ hybridization reveals that human SHANK3 mRNA expression varies during development and in autism-associated SHANK3 heterozygosity
por: Taylor, Samuel E., et al.
Publicado: (2018) -
Human pluripotent stem cell models of autism spectrum disorder: emerging frontiers, opportunities, and challenges towards neuronal networks in a dish
por: Aigner, Stefan, et al.
Publicado: (2013) -
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction
por: Peça, João, et al.
Publicado: (2011) -
Adult Restoration of Shank3 Expression Rescues Selective Autistic-Like Phenotypes
por: Mei, Yuan, et al.
Publicado: (2016) -
Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling
por: Pagano, Jessica, et al.
Publicado: (2023)