Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical development

Autism is a prevailing neurodevelopmental disorder with a large genetic/genomic component. Recently, the dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1 A (DYRK1A) gene was implicated as a risk factor for autism spectrum disorder (ASD). We identified five DYRK1A variants in ASD pati...

Descripción completa

Detalles Bibliográficos
Autores principales: Dang, T, Duan, W Y, Yu, B, Tong, D L, Cheng, C, Zhang, Y F, Wu, W, Ye, K, Zhang, W X, Wu, M, Wu, B B, An, Y, Qiu, Z L, Wu, B L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822466/
https://www.ncbi.nlm.nih.gov/pubmed/28167836
http://dx.doi.org/10.1038/mp.2016.253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822466/
https://www.ncbi.nlm.nih.gov/pubmed/28167836
http://dx.doi.org/10.1038/mp.2016.253

Ejemplares similares