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Extracellular α-synuclein levels are regulated by neuronal activity

BACKGROUND: α-Synuclein is a presynaptic protein abundant in the cytoplasmic compartment of neurons, whereas its presence in the extracellular space has also been observed under physiological conditions. Extracellular α-synuclein has pathological significance, exhibiting cellular toxicity and impair...

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Detalles Bibliográficos
Autores principales: Yamada, Kaoru, Iwatsubo, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822605/
https://www.ncbi.nlm.nih.gov/pubmed/29467003
http://dx.doi.org/10.1186/s13024-018-0241-0