Pegylated and liposomal doxorubicin is associated with high mortality and causes limited cardiotoxicity in mice

OBJECTIVE: We wanted to determine the impact of different doses of a pegylated and liposomal formulation of the cardiotoxic drug doxorubicin on cardiac function, fibrosis and survival in mice. The drug causes myocardial damage by producing reactive oxygen species, mitochondrial damage and lipid pero...

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Detalles Bibliográficos
Autores principales: Stark, Christoffer, Taimen, Pekka, Savunen, Timo, Koskenvuo, Juha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822632/
https://www.ncbi.nlm.nih.gov/pubmed/29467032
http://dx.doi.org/10.1186/s13104-018-3260-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822632/
https://www.ncbi.nlm.nih.gov/pubmed/29467032
http://dx.doi.org/10.1186/s13104-018-3260-6

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