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Trastuzumab Resistance: Role for Notch Signaling
Epidermal growth factor receptor-2 (ErbB-2/HER2) is a potent breast oncogene that has been shown to be amplified in 20% of breast cancers. Overexpression of ErbB-2 predicts for aggressive tumor behavior, resistance to some cytotoxic and antihormonal therapies, and poor overall survival. Trastuzumab,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
TheScientificWorldJOURNAL
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823123/ https://www.ncbi.nlm.nih.gov/pubmed/20024517 http://dx.doi.org/10.1100/tsw.2009.166 |