Cargando…

ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity

High temperature requirement A1 (HtrA1) belongs to an ancient protein family that is linked to various human disorders. The precise role of exon 1-encoded N-terminal domains and how these influence the biological functions of human HtrA1 remain elusive. In this study, we traced the evolutionary orig...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gerhardt, Maximilian J, Marsh, Joseph A, Morrison, Margaux, Kazlauskas, Andrius, Khadka, Arogya, Rosenkranz, Stephan, DeAngelis, Margaret M, Saint-Geniez, Magali, Jacobo, Sarah Melissa P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823240/ https://www.ncbi.nlm.nih.gov/pubmed/28992183 http://dx.doi.org/10.1093/jmcb/mjx024

Ejemplares similares

The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi
por: Chung, Hea-Jong, et al.
Publicado: (2020)

The family of Deg/HtrA proteases in plants
por: Schuhmann, Holger, et al.
Publicado: (2012)

Insights into the Cyanobacterial Deg/HtrA Proteases
por: Cheregi, Otilia, et al.
Publicado: (2016)

The proteolytic activity of Listeria monocytogenes HtrA
por: Abfalter, Carmen M., et al.
Publicado: (2019)

The Repeating, Modular Architecture of the HtrA Proteases
por: Merski, Matthew, et al.
Publicado: (2022)

PGC-1α Induces Human RPE Oxidative Metabolism and Antioxidant Capacity
por: Iacovelli, Jared, et al.
Publicado: (2016)

HtrA4 is up-regulated during trophoblast syncytialization and BeWo cells fail to syncytialize without HtrA4
por: Mansilla, Mary, et al.
Publicado: (2021)

Activity-Modulating Monoclonal Antibodies to the Human Serine Protease HtrA3 Provide Novel Insights into Regulating HtrA Proteolytic Activities
por: Singh, Harmeet, et al.
Publicado: (2014)

Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice
por: Gerhardt, Ellen, et al.
Publicado: (2011)

Borrelia burgdorferi HtrA may promote dissemination and irritation
por: Gherardini, Frank C
Publicado: (2013)

HtrA Is Important for Stress Resistance and Virulence in Haemophilus parasuis
por: Zhang, Luhua, et al.
Publicado: (2016)

Unraveling the Dichotomy of Enigmatic Serine Protease HtrA2
por: Chakraborty, Ayon, et al.
Publicado: (2022)

Identification and Characterization of an HtrA Sheddase Produced by Coxiella burnetii
por: Osman, Ikram Omar, et al.
Publicado: (2023)

Protease-independent control of parthanatos by HtrA2/Omi
por: Weiß, Jonas, et al.
Publicado: (2023)

Proteases HtrA and HtrB for α-amylase secreted from Bacillus subtilis in secretion stress
por: Yan, Shaomin, et al.
Publicado: (2019)

The Novel Role of HtrA1 in Gingivitis, Chronic and Aggressive Periodontitis
por: Lorenzi, Teresa, et al.
Publicado: (2014)

HtrA1 expression associated with the occurrence and development of esophageal cancer
por: Yu, Youtao, et al.
Publicado: (2012)

SHAPE analysis of the htrA RNA thermometer from Salmonella enterica
por: Choi, Edric K., et al.
Publicado: (2017)

HtrA1 in Gestational Diabetes Mellitus: A Possible Biomarker?
por: Tossetta, Giovanni, et al.
Publicado: (2022)

HtrA chaperone activity contributes to host cell binding in Campylobacter jejuni
por: Bæk, Kristoffer T, et al.
Publicado: (2011)

Temperature-induced changes of HtrA2(Omi) protease activity and structure
por: Zurawa-Janicka, Dorota, et al.
Publicado: (2012)

Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains
por: Glaza, Przemyslaw, et al.
Publicado: (2015)

Cloning and Transcriptional Activity of the Mouse Omi/HtrA2 Gene Promoter
por: Liu, Dan, et al.
Publicado: (2016)

Protoporphyrins Enhance Oligomerization and Enzymatic Activity of HtrA1 Serine Protease
por: Jo, Hakryul, et al.
Publicado: (2014)

HtrA1: Its future potential as a novel biomarker for cancer
por: ALTOBELLI, EMMA, et al.
Publicado: (2015)

HtrA2 suppresses autoimmune arthritis and regulates activation of STAT3
por: Lee, Seung Hoon, et al.
Publicado: (2016)

The expression of HtrA2 and its diagnostic value in patients with hepatocellular carcinoma
por: Wang, Honggang, et al.
Publicado: (2018)

HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication
por: Cabrera, Alvaro Cortes, et al.
Publicado: (2017)

Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2
por: Merski, Matthew, et al.
Publicado: (2017)

Function of Serine Protease HtrA in the Lifecycle of the Foodborne Pathogen Campylobacter jejuni
por: Boehm, Manja, et al.
Publicado: (2018)

Effect of HtrA1 Polymorphism on Sensitivity to Chemotherapy in Patients with Colon Cancer
por: Yao, Yi, et al.
Publicado: (2020)

HtrA4 Protease Promotes Chemotherapeutic-Dependent Cancer Cell Death
por: Wenta, Tomasz, et al.
Publicado: (2019)

Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ
por: Malet, Hélène, et al.
Publicado: (2012)

Calcium binding protects E-cadherin from cleavage by Helicobacter pylori HtrA
por: Schmidt, Thomas P., et al.
Publicado: (2016)

Generation and characterization of mice with a conditional null allele of the HtrA4 gene
por: LIU, JU, et al.
Publicado: (2015)

Bacterial serine protease HtrA as a promising new target for antimicrobial therapy?
por: Wessler, Silja, et al.
Publicado: (2017)

HtrA1 as a promising tissue marker in cancer: a meta-analysis
por: Altobelli, Emma, et al.
Publicado: (2018)

HtrA of Borrelia burgdorferi Leads to Decreased Swarm Motility and Decreased Production of Pyruvate
por: Coleman, James L., et al.
Publicado: (2018)

The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes
por: Rodrigue-Gervais, Ian Gaël, et al.
Publicado: (2018)

Quantification of serine protease HtrA molecules secreted by the foodborne pathogen Campylobacter jejuni
por: Neddermann, Matthias, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_d1c4rtrcmpgc07ogbeqs5kj4es