Offspring sex impacts DNA methylation and gene expression in placentae from women with diabetes during pregnancy

AIMS/HYPOTHESIS: We hypothesized that diabetes during pregnancy (DDP) alters genome-wide DNA methylation in placenta resulting in differentially methylated loci of metabolically relevant genes and downstream changes in RNA and protein expression. METHODS: We mapped genome-wide DNA methylation with t...

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Detalles Bibliográficos
Autores principales: Alexander, Jacqueline, Teague, April M., Chen, Jing, Aston, Christopher E., Leung, Yuet-Kin, Chernausek, Steven, Simmons, Rebecca A., Pinney, Sara E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823368/
https://www.ncbi.nlm.nih.gov/pubmed/29470513
http://dx.doi.org/10.1371/journal.pone.0190698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823368/
https://www.ncbi.nlm.nih.gov/pubmed/29470513
http://dx.doi.org/10.1371/journal.pone.0190698

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