Intracellular amyloid beta expression leads to dysregulation of the mitogen-activated protein kinase and bone morphogenetic protein-2 signaling axis

Alzheimer’s disease (AD) is a neurodegenerative syndrome classically depicted by the parenchymal accumulation of extracellular amyloid beta plaques. However, recent findings suggest intraneuronal amyloid beta (iAβ(1–42)) accumulation precedes extracellular deposition. Furthermore, the pathologic inc...

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Detalles Bibliográficos
Autores principales: Cruz, Eric, Kumar, Sushil, Yuan, Li, Arikkath, Jyothi, Batra, Surinder K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823380/
https://www.ncbi.nlm.nih.gov/pubmed/29470488
http://dx.doi.org/10.1371/journal.pone.0191696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823380/
https://www.ncbi.nlm.nih.gov/pubmed/29470488
http://dx.doi.org/10.1371/journal.pone.0191696

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