Cargando…

Intracellular amyloid beta expression leads to dysregulation of the mitogen-activated protein kinase and bone morphogenetic protein-2 signaling axis

Alzheimer’s disease (AD) is a neurodegenerative syndrome classically depicted by the parenchymal accumulation of extracellular amyloid beta plaques. However, recent findings suggest intraneuronal amyloid beta (iAβ(1–42)) accumulation precedes extracellular deposition. Furthermore, the pathologic inc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cruz, Eric, Kumar, Sushil, Yuan, Li, Arikkath, Jyothi, Batra, Surinder K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823380/ https://www.ncbi.nlm.nih.gov/pubmed/29470488 http://dx.doi.org/10.1371/journal.pone.0191696

Ejemplares similares

Synaptic dysregulation and hyperexcitability induced by intracellular amyloid beta oligomers
por: Fernandez‐Perez, Eduardo J., et al.
Publicado: (2021)

Corrigendum: Synaptic dysregulation and hyperexcitability induced by intracellular amyloid beta oligomers
Publicado: (2021)

The Role of Neutrophil Proteins on the Amyloid Beta-RAGE Axis
por: Stock, Amanda J., et al.
Publicado: (2016)

Mitogen-activated protein kinase phosphatase 1 protects PC12 cells from amyloid beta-induced neurotoxicity
por: Gu, Yue, et al.
Publicado: (2018)

Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold
por: Grabrucker, Andreas M, et al.
Publicado: (2011)

Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease
por: Ding, Yu, et al.
Publicado: (2019)

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
por: Pandey, Poomy, et al.
Publicado: (2016)

The novel amyloid-beta peptide aptamer inhibits intracellular amyloid-beta peptide toxicity
por: Wang, Xu, et al.
Publicado: (2013)

N-cadherin: stabilizing synapses
por: Arikkath, Jyothi
Publicado: (2010)

Molecular mechanisms of dendrite morphogenesis
por: Arikkath, Jyothi
Publicado: (2012)

Cartilage-derived morphogenetic protein-1 and cartilage-derived morphogenetic protein-2 are present in ligament fibroblasts and lead to chondrogenic differentiation
por: Bobacz, K, et al.
Publicado: (2003)

Hypermethylation Leads to Bone Morphogenetic Protein 6 Downregulation in Hepatocellular Carcinoma
por: He, Yinghua, et al.
Publicado: (2014)

Glucosamine affects intracellular signalling through inhibition of mitogen-activated protein kinase phosphorylation in human chondrocytes
por: Scotto d'Abusco, Anna, et al.
Publicado: (2007)

Bone morphogenetic protein 2-induced human dental pulp cell differentiation involves p38 mitogen-activated protein kinase-activated canonical WNT pathway
por: Yang, Jing, et al.
Publicado: (2015)

Electrochemical Immunosensors Developed for Amyloid-Beta and Tau Proteins, Leading Biomarkers of Alzheimer’s Disease
por: Sharma, Abhinav, et al.
Publicado: (2023)

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass
por: Winbanks, Catherine E., et al.
Publicado: (2013)

Editorial: Mitogen Activated Protein Kinases
por: Cuenda, Ana, et al.
Publicado: (2017)

Systematic Discovery of FBXW7-Binding Phosphodegrons Highlights Mitogen-Activated Protein Kinases as Important Regulators of Intracellular Protein Levels
por: Singh, Neha, et al.
Publicado: (2022)

Amyloid-beta Alzheimer targets — protein processing, lipid rafts, and amyloid-beta pores
por: Arbor, Sage C., et al.
Publicado: (2016)

Mitogen‐Activated Protein Kinase and Intracellular Polyamine Signaling Is Involved in TRPV1 Activation–Induced Cardiac Hypertrophy
por: Chen, Mai, et al.
Publicado: (2016)

Mitogen-activated protein kinases (MAPKs) are modulated during in vitro and in vivo infection with the intracellular bacterium Burkholderia pseudomallei
por: D’Elia, R. V., et al.
Publicado: (2017)

Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration
por: Schaefer, Patrick M., et al.
Publicado: (2016)

Is Mitogen‐Activated Protein Kinase Phosphatase 5 a Solution to the Puzzle of the Mitogen‐Activated Protein Kinase Signal in Steatohepatitis?
por: Miura, Kouichi, et al.
Publicado: (2019)

A mathematical model for the effects of amyloid beta on intracellular calcium
por: Latulippe, Joe, et al.
Publicado: (2018)

Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3
por: Bassi, Rekha, et al.
Publicado: (2017)

The Classic: Bone Morphogenetic Protein
por: Urist, Marshall R., et al.
Publicado: (2009)

Beta-Secretase 1 Recruits Amyloid-Beta Precursor Protein to ROCK2 Kinase, Resulting in Erroneous Phosphorylation and Beta-Amyloid Plaque Formation
por: Hajdú, István, et al.
Publicado: (2023)

Thrombomodulin Regulation of Mitogen-Activated Protein Kinases
por: Giri, Hemant, et al.
Publicado: (2019)

Amyloid Beta-Protein and Neural Network Dysfunction
por: Peña-Ortega, Fernando
Publicado: (2013)

Bone morphogenetic protein-4 and bone morphogenetic protein receptors expressions in the adult rat eye
por: Maruyama-Koide, Yuka, et al.
Publicado: (2017)

Inhibiting p38 mitogen-activated protein kinase attenuates cerebral ischemic injury in Swedish mutant amyloid precursor protein transgenic mice☆
por: Zou, Liangyu, et al.
Publicado: (2012)

Hepcidin promotes osteogenic differentiation through the bone morphogenetic protein 2/small mothers against decapentaplegic and mitogen-activated protein kinase/P38 signaling pathways in mesenchymal stem cells
por: LU, HUADING, et al.
Publicado: (2015)

Intracellular Calcium Dysregulation by the Alzheimer’s Disease-Linked Protein Presenilin 2
por: Galla, Luisa, et al.
Publicado: (2020)

The activation of p38alpha, and not p38beta, mitogen-activated protein kinase is required for ischemic preconditioning
por: Sicard, Pierre, et al.
Publicado: (2010)

The relation between mitogen activated protein kinase (MAPK) pathway and different genes expression in patients with beta Thalassemia
por: Elghobashy, Yasser AbdElsattar, et al.
Publicado: (2020)

Mitogen-Activated Protein Kinases and Mitogen Kinase Phosphatase 1: A Critical Interplay in Macrophage Biology
por: Lloberas, Jorge, et al.
Publicado: (2016)

Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system
por: Zheng, Lin, et al.
Publicado: (2012)

Effect of heat stress on mitogen-activated protein kinases in the hypothalamic–pituitary–gonadal axis of developing Wenchang chicks
por: Li, Q.H., et al.
Publicado: (2019)

Effects of bioactive glass S53P4 or beta-tricalcium phosphate and bone morphogenetic protein-2 and bone morphogenetic protein-7 on osteogenic differentiation of human adipose stem cells
por: Waselau, Martin, et al.
Publicado: (2012)

Genome-wide identification and transcriptional expression analysis of mitogen-activated protein kinase and mitogen-activated protein kinase kinase genes in Capsicum annuum
por: Liu, Zhiqin, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_gtv4qveqk207vq592m5qguidhm