Vehicle development, pharmacokinetics and toxicity of the anti-invasive agent 4-fluoro-3’,4’,5’-trimethoxychalcone in rodents

Effective inhibitors of invasion and metastasis represent a serious unmet clinical need. We have recently identified 4-fluoro-3’,4’,5’-trimethoxychalcone or C16 as a potent anti-invasive molecule. In this paper, we report on the development of an optimized vehicle for oral administration of C16. We...

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Detalles Bibliográficos
Autores principales: Mus, Liselot M., Denecker, Geertrui, Speleman, Frank, Roman, Bart I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823406/
https://www.ncbi.nlm.nih.gov/pubmed/29470507
http://dx.doi.org/10.1371/journal.pone.0192548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823406/
https://www.ncbi.nlm.nih.gov/pubmed/29470507
http://dx.doi.org/10.1371/journal.pone.0192548

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