A-674563, a putative AKT1 inhibitor that also suppresses CDK2 activity, inhibits human NSCLC cell growth more effectively than the pan-AKT inhibitor, MK-2206

AKT is a serine-threonine kinase implicated in tumorigenesis as a central regulator of cellular growth, proliferation, survival, and metabolism. Activated AKT is commonly overexpressed in non-small cell lung cancer (NSCLC) and accordingly AKT inhibitors are under clinical investigation for NSCLC tre...

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Detalles Bibliográficos
Autores principales: Chorner, Paige M., Moorehead, Roger A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823456/
https://www.ncbi.nlm.nih.gov/pubmed/29470540
http://dx.doi.org/10.1371/journal.pone.0193344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823456/
https://www.ncbi.nlm.nih.gov/pubmed/29470540
http://dx.doi.org/10.1371/journal.pone.0193344

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