FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway

FLT3-ITD is the most frequent tyrosine kinase mutation in acute myeloid leukemia (AML) associated with poor prognosis. We previously reported that activation of STAT5 confers resistance to PI3K/Akt inhibitors on the FLT3-ITD-positive AML cell line MV4-11 and 32D cells driven by FLT3-ITD (32D/ITD) bu...

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Detalles Bibliográficos
Autores principales: Okada, Keigo, Nogami, Ayako, Ishida, Shinya, Akiyama, Hiroki, Chen, Cheng, Umezawa, Yoshihiro, Miura, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823622/
https://www.ncbi.nlm.nih.gov/pubmed/29507660
http://dx.doi.org/10.18632/oncotarget.22926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823622/
https://www.ncbi.nlm.nih.gov/pubmed/29507660
http://dx.doi.org/10.18632/oncotarget.22926

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