Cargando…

VEGFR2-specific FnCAR effectively redirects the cytotoxic activity of T cells and YT NK cells

T and NK cells armed with chimeric antigen receptors (CAR) are promising tools for the specific elimination of cancer cells. In most CAR designs implemented to date, the recognition of target cells is mediated by single-chain variable fragments (scFvs) derived from murine monoclonal antibodies. This...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kulemzin, Sergey V., Gorchakov, Andrey A., Chikaev, Anton N., Kuznetsova, Valeriya V., Volkova, Olga Y., Matvienko, Daria A., Petukhov, Alexey V., Zaritskey, Andrey Y., Taranin, Alexandr V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823625/ https://www.ncbi.nlm.nih.gov/pubmed/29507671 http://dx.doi.org/10.18632/oncotarget.24078

Ejemplares similares

shp-2 gene knockout upregulates CAR-driven cytotoxicity of YT NK cells
por: Subrakova, V.G., et al.
Publicado: (2020)

Design and analysis of stably integrated reporters for inducible transgene expression in human T cells and CAR NK-cell lines
por: Kulemzin, Sergey V., et al.
Publicado: (2019)

Comparative Pre-Clinical Analysis of CD20-Specific CAR T Cells Encompassing 1F5-, Leu16-, and 2F2-Based Antigen-Recognition Moieties
por: Belovezhets, Tatyana, et al.
Publicado: (2023)

Horses for Courses in the Era of CARs: Advancing CAR T and CAR NK Cell Therapies
por: Kulemzin, Sergey, et al.
Publicado: (2021)

Engineering Chimeric Antigen Receptors
por: Kulemzin, S. V., et al.
Publicado: (2017)

VH3-53/66-Class RBD-Specific Human Monoclonal Antibody iB20 Displays Cross-Neutralizing Activity against Emerging SARS-CoV-2 Lineages
por: Kulemzin, Sergey V., et al.
Publicado: (2022)

Memory B Cells Induced by Sputnik V Vaccination Produce SARS-CoV-2 Neutralizing Antibodies Upon Ex Vivo Restimulation
por: Byazrova, Maria G., et al.
Publicado: (2022)

Isolation of a panel of ultra-potent human antibodies neutralizing SARS-CoV-2 and viral variants of concern
por: Gorchakov, Andrey A., et al.
Publicado: (2021)

Functional Profiling of In Vitro Reactivated Memory B Cells Following Natural SARS-CoV-2 Infection and Gam-COVID-Vac Vaccination
por: Astakhova, Ekaterina A., et al.
Publicado: (2022)

Strategies to Circumvent the Side-Effects of Immunotherapy Using Allogeneic CAR-T Cells and Boost Its Efficacy: Results of Recent Clinical Trials
por: Smirnov, Sergei, et al.
Publicado: (2021)

Diversity of Immunoglobulin Light Chain Genes in Non-Teleost Ray-Finned Fish Uncovers IgL Subdivision into Five Ancient Isotypes
por: Guselnikov, Sergey V., et al.
Publicado: (2018)

Characterization of a New Cyclohexylamine Oxidase From Acinetobacter sp. YT-02
por: Zhou, Hui, et al.
Publicado: (2018)

Antibacterial and antibiofilm potential of Lacticaseibacillus rhamnosus YT and its cell-surface extract
por: Guan, Chengran, et al.
Publicado: (2023)

VEGFR-2 redirected CAR-T cells are functionally impaired by soluble VEGF-A competition for receptor binding
por: Lanitis, Evripidis, et al.
Publicado: (2021)

The ER Repeat Protein Yt521-B Localizes to a Novel Subnuclear Compartment
por: Nayler, Oliver, et al.
Publicado: (2000)

FN-EDA mediates angiogenesis of hepatic fibrosis via integrin-VEGFR2 in a CD63 synergetic manner
por: Su, Xiaonan, et al.
Publicado: (2020)

Structure of unliganded membrane-proximal domains FN4-FN5-FN6 of DCC
por: Finci, Lorenzo I., et al.
Publicado: (2017)

YT521-B homology domain family proteins as N6-methyladenosine readers in tumors
por: Yang, Heng, et al.
Publicado: (2022)

Expression of YT Domain Family Protein in Oral Squamous Cell Carcinoma and Its Correlation with the Prognosis
por: Shi, Rui, et al.
Publicado: (2023)

Biodegradation of Di-(2-ethylhexyl) Phthalate by Rhodococcus ruber YC-YT1 in Contaminated Water and Soil
por: Yang, Ting, et al.
Publicado: (2018)

Implications for Collagen Binding from the Crystallographic Structure of Fibronectin (6)FnI(1–2)FnII(7)FnI
por: Erat, Michèle C., et al.
Publicado: (2010)

Experimental Diagnostics of the Emotional State of Individuals Using External Stimuli and a Model of Neurocognitive Brain Activity
por: Petukhov, Alexandr Y., et al.
Publicado: (2022)

A Novel Nitrite-Base Aerobic Denitrifying Bacterium Acinetobacter sp. YT03 and Its Transcriptome Analysis
por: Li, Bin, et al.
Publicado: (2019)

Anti-Gastric Cancer Activity of the Cell-free Culture Supernatant of Serofluid Dish and Lactiplantibacillus plantarum YT013
por: Zhang, Rentao, et al.
Publicado: (2022)

Unraveling the LRC Evolution in Mammals: IGSF1 and A1BG Provide the Keys
por: Guselnikov, Sergey V, et al.
Publicado: (2019)

The third restriction–modification system from Thermus aquaticus YT-1: solving the riddle of two TaqII specificities
por: Skowron, Piotr M., et al.
Publicado: (2017)

The modular pYT vector series employed for chromosomal gene integration and expression to produce carbazoles and glycolipids in P. putida
por: Weihmann, Robin, et al.
Publicado: (2022)

The presence of Anf/Hesx1 homeobox gene in lampreys suggests that it could play an important role in emergence of telencephalon
por: Bayramov, Andrey V., et al.
Publicado: (2016)

A Novel Her2/VEGFR2/CD3 trispecific antibody with an optimal structural design showed improved T-cell-redirecting antitumor efficacy
por: Liu, Dong, et al.
Publicado: (2022)

Genetic Redirection of T Cells for the Treatment of Pancreatic Cancer
por: Ali, Aesha I., et al.
Publicado: (2019)

The Advantages and Challenges of Anticancer Dendritic Cell Vaccines and NK Cells in Adoptive Cell Immunotherapy
por: Abakushina, Elena V., et al.
Publicado: (2021)

Cytotoxic secondary metabolites isolated from Penicillium sp. YT2019-3321, an endophytic fungus derived from Lonicera Japonica
por: Weng, Wenya, et al.
Publicado: (2022)

Functional properties of bone marrow derived multipotent mesenchymal stromal cells are altered in heart failure patients, and could be corrected by adjustment of expansion strategies
por: Dmitrieva, Renata I., et al.
Publicado: (2015)

Attenuation of RNA viruses by redirecting their evolution in sequence space
por: Moratorio, Gonzalo, et al.
Publicado: (2017)

Preparation and Characterization of Facilitated Transport Membranes Composed of Chitosan-Styrene and Chitosan-Acrylonitrile Copolymers Modified by Methylimidazolium Based Ionic Liquids for CO(2) Separation from CH(4) and N(2)
por: Otvagina, Ksenia V., et al.
Publicado: (2016)

Parallel synthesis and splicing redirection activity of cell-penetrating peptide conjugate libraries of a PNA cargo
por: Deuss, Peter J., et al.
Publicado: (2013)

Contextual Impairments in Schizophrenia and the FN400
por: Amoruso, Lucia, et al.
Publicado: (2012)

TWEAK and Fn14 in the Neurovascular Unit
por: Yepes, Manuel
Publicado: (2013)

Highly conserved salt bridge stabilizes a proteinase K subfamily enzyme, Aqualysin I, from Thermus aquaticus YT-1
por: Sakaguchi, Masayoshi, et al.
Publicado: (2014)

The Effect of Lactobacillus acidophilus YT1 (MENOLACTO) on Improving Menopausal Symptoms: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
por: Lim, Eun Yeong, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0um48gcnm1l1kd6mkbn7itmk3o