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Development of novel miR-129 mimics with enhanced efficacy to eliminate chemoresistant colon cancer stem cells
BACKGROUND: Resistance to 5-Fluorouracil (5-FU) based chemotherapy is the major reason for failure of treating patients with advanced colorectal cancer. MATERIALS AND METHODS: In this study, we developed a novel miR-129 mimic with potent efficacy in eliminating resistant colon cancer stem cells both...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823633/ https://www.ncbi.nlm.nih.gov/pubmed/29507661 http://dx.doi.org/10.18632/oncotarget.22322 |