Cargando…

Notoginsenoside R1 ameliorates diabetic encephalopathy by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

Numerous researches supported that oxidative stress and inflammation play important roles in the development of diabetic encephalopathy (DEP). Notoginsenoside R1 (NGR1), one major component of Panax notoginseng, is believed to have anti-oxidative, anti-inflammatory and neuroprotective properties. Ho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhai, Yadong, Meng, Xiangbao, Luo, Yun, Wu, Yongmei, Ye, Tianyuan, Zhou, Ping, Ding, Shilan, Wang, Min, Lu, Senbao, Zhu, Lili, Sun, Guibo, Sun, Xiaobo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823646/ https://www.ncbi.nlm.nih.gov/pubmed/29507694 http://dx.doi.org/10.18632/oncotarget.24295

Ejemplares similares

Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice
por: Zhai, Yadong, et al.
Publicado: (2018)

Gastrodin Ameliorates Cognitive Dysfunction in Diabetes Rat Model via the Suppression of Endoplasmic Reticulum Stress and NLRP3 Inflammasome Activation
por: Ye, Tianyuan, et al.
Publicado: (2018)

Notoginsenoside R1 Ameliorates Diabetic Retinopathy through PINK1-Dependent Activation of Mitophagy
por: Zhou, Ping, et al.
Publicado: (2019)

Correction: Zhou, P., et al. Notoginsenoside R1 Ameliorates Diabetic Retinopathy through PINK1-Dependent Activation of Mitophagy. Cells, 2019, 8, 213
por: Zhou, Ping, et al.
Publicado: (2020)

Gastrodin Alleviates Cognitive Dysfunction and Depressive-Like Behaviors by Inhibiting ER Stress and NLRP3 Inflammasome Activation in db/db Mice
por: Ye, Tianyuan, et al.
Publicado: (2018)

Notoginsenoside R1 Improves Cerebral Ischemia/Reperfusion Injury by Promoting Neurogenesis via the BDNF/Akt/CREB Pathway
por: Zhu, Ting, et al.
Publicado: (2021)

Notoginsenoside R1 Protects db/db Mice against Diabetic Nephropathy via Upregulation of Nrf2-Mediated HO-1 Expression
por: Zhang, Bin, et al.
Publicado: (2019)

Panax Notoginseng Saponins: A Review of Its Mechanisms of Antidepressant or Anxiolytic Effects and Network Analysis on Phytochemistry and Pharmacology
por: Xie, Weijie, et al.
Publicado: (2018)

Notoginsenoside R1 Protects Against Diabetic Cardiomyopathy Through Activating Estrogen Receptor α and Its Downstream Signaling
por: Zhang, Bin, et al.
Publicado: (2018)

Dai-Zong-Fang, A Traditional Chinese Herbal Formula, Ameliorates Insulin Resistance in db/db Mice
por: Zhu, Lili, et al.
Publicado: (2018)

Rosiglitazone ameliorates acute hepatic injury via activating the Nrf2 signaling pathway and inhibiting activation of the NLRP3 inflammasome
por: Ma, Ling, et al.
Publicado: (2022)

Hydroxysafflor Yellow A Protects Against Myocardial Ischemia/Reperfusion Injury via Suppressing NLRP3 Inflammasome and Activating Autophagy
por: Ye, Jingxue, et al.
Publicado: (2020)

Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation
por: Yu, Xianjun, et al.
Publicado: (2017)

Ruscogenin Ameliorated Sjögren's Syndrome by Inhibiting NLRP3 Inflammasome Activation
por: He, Jing, et al.
Publicado: (2022)

Corrigendum: Hydroxysafflor Yellow A Protects Against Myocardial Ischemia/Reperfusion Injury via Suppressing NLRP3 Inflammasome and Activating Autophagy
por: Ye, Jingxue, et al.
Publicado: (2021)

Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis
por: Chen, Zhuming, et al.
Publicado: (2019)

Cardioprotective effects of Notoginsenoside R1 against ischemia/reperfusion injuries by regulating oxidative stress- and endoplasmic reticulum stress- related signaling pathways
por: Yu, Yingli, et al.
Publicado: (2016)

Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway
por: Tian, Xue, et al.
Publicado: (2022)

Notoginsenoside R(1) prevents H9c2 cardiomyocytes apoptosis against hypoxia/reoxygenation via the ERs/PI3K/Akt pathway
por: Li, Guang, et al.
Publicado: (2018)

Colchicine Ameliorates Dilated Cardiomyopathy Via SIRT2‐Mediated Suppression of NLRP3 Inflammasome Activation
por: Sun, Xuan, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives and Analogs Targeting the NLRP3 Inflammasome
por: Pan, Liangkun, et al.
Publicado: (2017)

Maf1 Ameliorates Sepsis-Associated Encephalopathy by Suppressing the NF-kB/NLRP3 Inflammasome Signaling Pathway
por: Chen, Shenglong, et al.
Publicado: (2020)

Kynurenic acid ameliorates NLRP3 inflammasome activation by blocking calcium mobilization via GPR35
por: Sun, Tianyin, et al.
Publicado: (2022)

Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome Inhibition
por: Ma, Sai, et al.
Publicado: (2018)

Inhibition of the NLRP3 Inflammasome Activation by Manoalide Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis
por: Li, Cong, et al.
Publicado: (2022)

Hyperammonemia induces microglial NLRP3 inflammasome activation via mitochondrial oxidative stress in hepatic encephalopathy
por: Cheon, So Yeong, et al.
Publicado: (2023)

NLRP3 Inflammasome Activation by Viroporins of Animal Viruses
por: Guo, Hui-Chen, et al.
Publicado: (2015)

NLRP3 inflammasome activation is involved in manganese-induced immunotoxicity: Mn activates macrophage NLRP3 inflammasome
por: Ji, Jing, et al.
Publicado: (2021)

Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling
por: Yu, Ye, et al.
Publicado: (2020)

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease
por: Saresella, Marina, et al.
Publicado: (2016)

GPA peptide inhibits NLRP3 inflammasome activation to ameliorate colitis through AMPK pathway
por: Deng, Zhao, et al.
Publicado: (2020)

Sinapine Thiocyanate Ameliorates Vascular Endothelial Dysfunction in Hypertension by Inhibiting Activation of the NLRP3 Inflammasome
por: Liu, Yang, et al.
Publicado: (2021)

AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation
por: Kong, Lijun, et al.
Publicado: (2021)

Nebivolol Ameliorates Cardiac NLRP3 Inflammasome Activation in a Juvenile-Adolescent Animal Model of Diet-Induced Obesity
por: Xie, Qihai, et al.
Publicado: (2016)

Notoginseng leaf triterpenes ameliorates mitochondrial oxidative injury via the NAMPT-SIRT1/2/3 signaling pathways in cerebral ischemic model rats
por: Xie, Weijie, et al.
Publicado: (2023)

Protective effects of sulforaphane on diabetic retinopathy: activation of the Nrf2 pathway and inhibition of NLRP3 inflammasome formation
por: Li, Sheng, et al.
Publicado: (2019)

Isoquercitrin Attenuates Steatohepatitis by Inhibition of the Activated NLRP3 Inflammasome through HSP90
por: Ma, Ji, et al.
Publicado: (2023)

Research Progress of Mitochondrial Mechanism in NLRP3 Inflammasome Activation and Exercise Regulation of NLRP3 Inflammasome
por: Zhang, Tan, et al.
Publicado: (2021)

TRPM2 links oxidative stress to the NLRP3 inflammasome activation
por: Zhong, Zhenyu, et al.
Publicado: (2013)

Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression
por: Du, Ren-Hong, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_2mjug5njueteam3tvobk2g0ln9