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Micro-pharmacokinetics: Quantifying local drug concentration at live cell membranes
Fundamental equations for determining pharmacological parameters, such as the binding affinity of a ligand for its target receptor, assume a homogeneous distribution of ligand, with concentrations in the immediate vicinity of the receptor being the same as those in the bulk aqueous phase. It is, how...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823863/ https://www.ncbi.nlm.nih.gov/pubmed/29472588 http://dx.doi.org/10.1038/s41598-018-21100-x |