Gα(i)-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation

Hypertension and aneurysm are frequently associated with autosomal dominant polycystic kidney disease (ADPKD) caused by polycystin-1 (PC1) mutations, which is closely related to endothelial dysfunction. PC1 is an atypical G-protein-coupled receptor that activates G-proteins by self-cleavage; current...

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Detalles Bibliográficos
Autores principales: Kwak, Misun, Hong, Chansik, Myeong, Jongyun, Park, Eunice Yon June, Jeon, Ju-Hong, So, Insuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823873/
https://www.ncbi.nlm.nih.gov/pubmed/29472562
http://dx.doi.org/10.1038/s41598-018-21873-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823873/
https://www.ncbi.nlm.nih.gov/pubmed/29472562
http://dx.doi.org/10.1038/s41598-018-21873-1

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