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Gα(i)-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation
Hypertension and aneurysm are frequently associated with autosomal dominant polycystic kidney disease (ADPKD) caused by polycystin-1 (PC1) mutations, which is closely related to endothelial dysfunction. PC1 is an atypical G-protein-coupled receptor that activates G-proteins by self-cleavage; current...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823873/ https://www.ncbi.nlm.nih.gov/pubmed/29472562 http://dx.doi.org/10.1038/s41598-018-21873-1 |