The structure of iPLA(2)β reveals dimeric active sites and suggests mechanisms of regulation and localization

Calcium-independent phospholipase A(2)β (iPLA(2)β) regulates important physiological processes including inflammation, calcium homeostasis and apoptosis. It is genetically linked to neurodegenerative disorders including Parkinson’s disease. Despite its known enzymatic activity, the mechanisms underl...

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Detalles Bibliográficos
Autores principales: Malley, Konstantin R., Koroleva, Olga, Miller, Ian, Sanishvili, Ruslan, Jenkins, Christopher M., Gross, Richard W., Korolev, Sergey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823874/
https://www.ncbi.nlm.nih.gov/pubmed/29472584
http://dx.doi.org/10.1038/s41467-018-03193-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823874/
https://www.ncbi.nlm.nih.gov/pubmed/29472584
http://dx.doi.org/10.1038/s41467-018-03193-0

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