Cargando…
The structure of iPLA(2)β reveals dimeric active sites and suggests mechanisms of regulation and localization
Calcium-independent phospholipase A(2)β (iPLA(2)β) regulates important physiological processes including inflammation, calcium homeostasis and apoptosis. It is genetically linked to neurodegenerative disorders including Parkinson’s disease. Despite its known enzymatic activity, the mechanisms underl...
Autores principales: | Malley, Konstantin R., Koroleva, Olga, Miller, Ian, Sanishvili, Ruslan, Jenkins, Christopher M., Gross, Richard W., Korolev, Sergey |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823874/ https://www.ncbi.nlm.nih.gov/pubmed/29472584 http://dx.doi.org/10.1038/s41467-018-03193-0 |
Ejemplares similares
-
Phospholipase iPLA(2)β Averts Ferroptosis By Eliminating A Redox Lipid Death Signal
por: Sun, Wan-Yang, et al.
Publicado: (2021) -
Phospholipase iPLA2β acts as a guardian against ferroptosis
por: Mao, Chao, et al.
Publicado: (2021) -
iPLA(2)β: front and center in human monocyte chemotaxis to MCP-1
por: Mishra, Ravi S., et al.
Publicado: (2008) -
High-fat diet activates liver iPLA(2)γ generating eicosanoids that mediate metabolic stress
por: Moon, Sung Ho, et al.
Publicado: (2021) -
Long-Term Lithium Treatment Increases cPLA(2) and iPLA(2) Activity in Cultured Cortical and Hippocampal Neurons
por: De-Paula, Vanessa de Jesus, et al.
Publicado: (2015)