Cargando…

Nanogels of dual inhibitor-modified hyaluronic acid function as a potent inhibitor of amyloid β-protein aggregation and cytotoxicity

Inhibition of amyloid β-protein (Aβ) aggregation is considered as a promising strategy for the prevention and treatment of Alzheimer’s disease. Epigallocatechin-3-gallate (EGCG) and curcumin have been recognized as effective inhibitors of Aβ aggregation. Herein, we proposed dual-inhibitor modificati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Zhiqiang, Dong, Xiaoyan, Yan, Xin, Liu, Yang, Zhang, Lin, Sun, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823891/ https://www.ncbi.nlm.nih.gov/pubmed/29472606 http://dx.doi.org/10.1038/s41598-018-21933-6

Ejemplares similares

Novel curcumin derivatives as potent inhibitors of amyloid β aggregation
por: Yanagisawa, Daijiro, et al.
Publicado: (2015)

Novel harmine derivatives as potent acetylcholinesterase and amyloid beta aggregation dual inhibitors for management of Alzheimer’s disease
por: Du, Hongtao, et al.
Publicado: (2023)

β-Carotene, a Potent Amyloid Aggregation Inhibitor, Promotes Disordered Aβ Fibrillar Structure
por: Banerjee, Siddhartha, et al.
Publicado: (2023)

The Dual Modification of PNIPAM and β-Cyclodextrin Grafted on Hyaluronic Acid as Self-Assembled Nanogel for Curcumin Delivery
por: Kaewruethai, Tisana, et al.
Publicado: (2022)

Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors
por: Bhatia, Sumati, et al.
Publicado: (2020)

Natural Inhibitors of Amyloid Aggregation
por: Tortora, Paolo, et al.
Publicado: (2023)

Design of Diarylheptanoid Derivatives as Dual Inhibitors Against Class IIa Histone Deacetylase and β-amyloid Aggregation
por: Chen, Liang-Chieh, et al.
Publicado: (2018)

Dual-target ligand discovery for Alzheimer’s disease: triphenylphosphoranylidene derivatives as inhibitors of acetylcholinesterase and β-amyloid aggregation
por: El-Hussieny, Marwa, et al.
Publicado: (2023)

β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor
por: Mirecka, Ewa A., et al.
Publicado: (2016)

Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation
por: Lu, Jinxia, et al.
Publicado: (2019)

Effective screen for amyloid β aggregation inhibitor using amyloid β-conjugated gold nanoparticles
por: Han, Sun-Ho, et al.
Publicado: (2011)

Self‐Stabilized Hyaluronate Nanogel for Intracellular Codelivery of Doxorubicin and Cisplatin to Osteosarcoma
por: Zhang, Yi, et al.
Publicado: (2018)

Self‐Stabilized Hyaluronate Nanogel for Intracellular Codelivery of Doxorubicin and Cisplatin to Osteosarcoma
por: Zhang, Yi, et al.
Publicado: (2018)

Dual-responsive degradable core–shell nanogels with tuneable aggregation behaviour
por: Gray, Dominic M., et al.
Publicado: (2022)

Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended In Cellulo, In Silico, and Kinetic Studies of Multifunctional Anti-Alzheimer’s Agents
por: Pasieka, Anna, et al.
Publicado: (2021)

Insights and Ideas Garnered from Marine Metabolites for Development of Dual-Function Acetylcholinesterase and Amyloid-β Aggregation Inhibitors
por: Stoddard, Shana V., et al.
Publicado: (2014)

Short Peptides as Inhibitors of Amyloid Aggregation
por: Neddenriep, Bradley, et al.
Publicado: (2011)

TMPyP Inhibits Amyloid-β Aggregation and Alleviates Amyloid-Induced Cytotoxicity
por: Fan, Yujuan, et al.
Publicado: (2017)

In Vitro Intestinal Uptake And Permeability Of Fluorescently-Labelled Hyaluronic Acid Nanogels
por: Xavier, Miguel, et al.
Publicado: (2019)

Encapsulation of SAAP-148 in Octenyl Succinic Anhydride-Modified Hyaluronic Acid Nanogels for Treatment of Skin Wound Infections
por: van Gent, Miriam E., et al.
Publicado: (2023)

Preparation of Cholesterol-Modified Hyaluronic Acid Nanogel-Based Hydrogel and the Inflammatory Evaluation Using Macrophage-like Cells
por: Yabuuchi, Kohei, et al.
Publicado: (2023)

Multicomponent Synthesis of Polyphenols and Their In Vitro Evaluation as Potential β-Amyloid Aggregation Inhibitors
por: Galante, Denise, et al.
Publicado: (2019)

pH and Reduction Dual-Responsive Nanogels as Smart Nanocarriers to Resist Doxorubicin Aggregation
por: Maruf, Ali, et al.
Publicado: (2022)

Silk peptide-hyaluronic acid based nanogels for the enhancement of the topical administration of curcumin
por: Niu, Jiangxiu, et al.
Publicado: (2022)

Synthesis and Biological Assessment of 2-Hydroxyiminoethanones as Anti-Inflammatory and β-Amyloid Aggregation Inhibitors
por: Valipour, Mehdi, et al.
Publicado: (2019)

The Tumor-Selective Cytotoxic Agent β-Lapachone is a Potent Inhibitor of IDO1
por: Flick, Hollie E., et al.
Publicado: (2013)

Nanogel-Facilitated In-Situ Delivery of a Cataract Inhibitor
por: Gautam, Dixa, et al.
Publicado: (2021)

d-Amino Acid Pseudopeptides as Potential Amyloid-Beta Aggregation Inhibitors
por: Mehrazma, Banafsheh, et al.
Publicado: (2018)

Hyaluronic acid-modified and verteporfin-loaded polylactic acid nanogels promote scarless wound healing by accelerating wound re-epithelialization and controlling scar formation
por: Chen, Kun, et al.
Publicado: (2023)

Discovery of Nobiletin from Citrus Peel as a Potent Inhibitor of β-Amyloid Peptide Toxicity
por: Youn, Kumju, et al.
Publicado: (2019)

Identification of a New Function of Cardiovascular Disease Drug 3-Morpholinosydnonimine Hydrochloride as an Amyloid-β Aggregation Inhibitor
por: Ren, Baiping, et al.
Publicado: (2017)

Synthesis and Characterization of Conjugated Hyaluronic Acids. Application to Stability Studies of Chitosan-Hyaluronic Acid Nanogels Based on Fluorescence Resonance Energy Transfer
por: Malytskyi, Volodymyr, et al.
Publicado: (2022)

Identifying Phlorofucofuroeckol-A as a Dual Inhibitor of Amyloid-β(25-35) Self-Aggregation and Insulin Glycation: Elucidation of the Molecular Mechanism of Action
por: Seong, Su Hui, et al.
Publicado: (2019)

Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function
por: Palanikumar, L., et al.
Publicado: (2021)

Temperature and pH Dual Responsive Nanogels of Modified Sodium Alginate and NIPAM for Berberine Loading and Release
por: Chang, Shuhua, et al.
Publicado: (2021)

In Silico Drug Design and Analysis of Dual Amyloid-Beta and Tau Protein-Aggregation Inhibitors for Alzheimer’s Disease Treatment
por: Job, Nisha, et al.
Publicado: (2023)

Using bacterial inclusion bodies to screen for amyloid aggregation inhibitors
por: Villar-Piqué, Anna, et al.
Publicado: (2012)

De novo designed protein inhibitors of amyloid aggregation and seeding
por: Murray, Kevin A., et al.
Publicado: (2022)

Rational Design of a Peptidomimetic Inhibitor of Gelsolin Amyloid Aggregation
por: Bollati, Michela, et al.
Publicado: (2022)

A Systematic Screening of Traditional Chinese Medicine Identifies Two Novel Inhibitors Against the Cytotoxic Aggregation of Amyloid Beta
por: Ma, Liang, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1lhrpo3h0tbmh9qm2pn38789bl