Broad blocking of MDR efflux pumps by acetylshikonin and acetoxyisovalerylshikonin to generate hypersensitive phenotype of malignant carcinoma cells

Cytotoxic activities of acetylshikonin and acetoxyisovalerylshikonin alone and in combination with chemotherapeutic agents against parental and drug resistant cell lines were determined using the MTT assay. Effects of Shikonin derivatives on BCRP, MDR1 and MRP transcript and protein levels were rela...

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Detalles Bibliográficos
Autores principales: Mirzaei, Seyed Abbas, Reiisi, Somayeh, Ghiasi Tabari, Parmida, Shekari, Abolfazl, Aliakbari, Fatemeh, Azadfallah, Elaheh, Elahian, Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823906/
https://www.ncbi.nlm.nih.gov/pubmed/29472576
http://dx.doi.org/10.1038/s41598-018-21710-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823906/
https://www.ncbi.nlm.nih.gov/pubmed/29472576
http://dx.doi.org/10.1038/s41598-018-21710-5

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