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Transcription Factor Target Gene Network governs the Logical Abstraction Analysis of the Synthetic Circuit in Leishmaniasis

With the advent of synthetic biology in medicine many synthetic or engineered proteins have made their way to therapeutics and diagnostics. In this paper, the downstream gene network of CD14-TNF-EGFR pathway in leishmaniasis, a tropical disease, is reconstructed. Network analysis showed that NFkB li...

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Detalles Bibliográficos
Autores principales: Mol, Milsee, Kosey, Dipali, Boppana, Ramanamurthy, Singh, Shailza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823942/
https://www.ncbi.nlm.nih.gov/pubmed/29472639
http://dx.doi.org/10.1038/s41598-018-21840-w